Rats were devided into five groups consisting of three treatment groups and two control groups. This is explained by the function of EDNO that mediate endothelium dependent vasodilatation, anti-inflammatory and antithrombotic effects [35,36]. Johnsen S, Lilleng H. Creatine kinase activity and blood pressure in a normal population: the tromsø study. The prevalence of diabetes mellitus has reached epidemic proportion in Malaysia and worldwide. 2014;16:624. The Malaysian National Health and Morbidity Survey (NHMS) in 2011 reported that the prevalence of hypertension in adult above 18 years of age was 35.1%. 2014;16:14–26. Piper sarmentosum has found a new home at JNTBGRI after the 2004 tsunami See black pepper for more infor­mation.. Nasim Habibzadeh MA. antioxidant properties. Many drugs prescribed for the treatment of hypertension do not tackle the underlying problem because the exact aetiology of hypertension remains unknown. *P < 0.05; compared to positive control, αP < 0.05; compared to baseline. The benefits of various herbs on the oxidative stress related disorders like DM and atherosclerosis have been well documented. NO is usually released by an intact endothelial wall [29] and causes vasodilatation. Reduced availability of NO is the hallmark of endothelial dysfunction [32]. statement and Mombouli J, Vanhoutte P. Endothelial dysfunction: from physiology to therapy. This study was conducted to identify and quantify the phenolic compounds of the leaf and fruit extract of P. sarmentosum, as well as Kadukmy™ supplementations in this study demonstrated attenuation of blood pressure and increase NO level. Lipid peroxidation has been recognized as a major process of cellular injury in animal biological systems. 2011;29(1):36–42. Data are denoted as mean ± S.E.M of n = 8 for treatment groups and n = 6 in the control groups. 2014;20(1):164–82. Picking D, Younger N, Mitchell S, Delgoda R. The prevalence of herbal medicine home use and concomitant use with pharmaceutical medicines in Jamaica. The writings from Egyptian papyrus and Ancient Chinese had described the usage of herbs as medicine as early as 3,000 B.C [27]. If you are interested, go to my store on Etsy.com My name on Etsy is: SpecialtyThings or you can just search for Piper Betel I have small, medium, and large plants that are up to 24 inches tall. California Privacy Statement, Proc Natl Acad Sci U S A. Du S, Neiman A, Batis C. Understanding the patterns and trends of sodium intake, potassium intake, and sodium to potassium ratio and their effect on hypertension in China. Hypertension is still treated by conventional medicine despite its exact aetiology being unknown. Piper sarmentosum(PS) is a traditional herb which is well-known for possessing antidiabeticproperties. Since betel is an aromatic creeper, you can easily grow it as an ornamental plant in your homes and derive the maximum health benefits … 0. Sub-acute exposure of PS leaves aqueous extract in animal study is safe and did not show toxic effect [26]. PS has been reported to possess high antioxidant compound [22]. Kelm M. The L-arginine-nitric oxide pathway in hypertension. The plant belongs to the family Piperaceae and is one of the most extensively used medicinal plants in the Ayurvedic system of medicine, particularly for diseases of respiratory tract. Endothelial dysfunction and over activity of the sympathetic and renin angiotensin aldosterone system were also reported to cause hypertension [7]. and 6 normotensive Wistar rats were obtained from Animal Unit of Universiti Kebangsaan Malaysia (UKM). Glucocorticoid treatment is the leading cause of secondary osteoporosis. Osteoporosis is characterized by the loss of bone mass and To. J Mol Cell Cardiol. BMC Complement Altern Med 15, 54 (2015). The use of Piper sarmentosum leaves aqueous extract (Kadukmy™) as antihypertensive agent in spontaneous hypertensive rats. Abstract:Osteoporosis is a major global health problem. Plantae > Tracheophyta > Magnoliopsida > Piperales > Piperaceae > Piper > Piper sarmentosum Roxb. (PS) is a medicinal plant reported to possess various biological properties, including anti-inflammatory, anti-psychotic and anti-oxidant activity. Heitzer T, Schlinzig T, Krohn K, Meinertz T, Münzel T. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Data are denoted as mean ± S.E.M of n = 8 for treatment groups and n = 6 in the control groups. Study showed that long term use of exogenous antioxidant rich supplement was able to improve blood pressure and ED, reduced arterial stiffness and atherosclerosis [13,14]. Data are denoted as mean ± S.E.M of n = 8 for treatment groups and n = 6 in the control groups. Manage cookies/Do not sell my data we use in the preference centre. (11β-HSD1). The main source of energy for the heart is dominantly from fat and it also relies on lactate and glucose as its energy reservoir [30]. Thus, it is proven that administration of Kadukmy™ supplementation for 4 weeks has no effect on cardiac tissue injury in SHR. Though its primary purpose is to be used as a mouth freshener, many people also use it for the numerous health benefits that it provides. For example, the polyunsaturated fatty acid peroxide end product is MDA. CAS  Hypertens Res. HongZhuan Y, Long L, Jun F. Involvement of reactive oxygen species in hypertension: its roles, production and therapeutic strategies. CPK is present in variable tissues that rapidly consume and buffer adenosine triphosphate (ATP), predominantly in the heart [43], brain and skeletal muscle. Endothelial dysfunction causes imbalance of the vasodilator system’s homeostasis especially involving the production and metabolism of NO [12]. Elvy Suhana Mohd Ramli, Subramaniam V, Adenan M, Ahmad A, Sahdan R. Natural antioxidants: piper sarmentosum (Kadok) and morinda elliptica (Mengkudu). Baseline blood investigations were done before and following commencement of treatment. 2011;11(1):31. No changes were observed in the heart rate of all rats throughout the study period (Figure 4). FRESH CUT LEAVES ONLY. strength which leads to an increased risk of fracture. BMC Complementary and Alternative Medicine It has long been used traditionally as a herbal medicine to treat diabetes, hypertension, and joint aches, toothache, coughing, pleurisy, fever, headache, feet dermatomycoses, and indigestion. Data are denoted as mean ± SEM of n = 8 for treatment groups and n = 6 in the control groups. Malaysia. 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