REACH regulation aims to improve the protection of human health and the environment from the risks that can be posed by chemicals. This substance is used in the following areas: formulation of mixtures and/or re-packaging. ... or the UN Global Harmonised System ... Methylene diphenyl diisocyanate . the electronic edition of the Official Journal of the European Union. This section provides an overview of the calculated volume at which the substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). 101-68-8 and 9016-87-9) in Support of Summary Information on the Integrated Risk Information System (IRIS). It may be toxic by … Precautionary statements - describe recommended measures to minimise or prevent adverse effects resulting from exposure to a hazardous product or improper storage or handling of a hazardous product. C&L Inventory . It is the responsibility of the substance manufacturers and importers to consult official publications, e.g. Gilbert, D.C. Allport, January 2001 ... MDI methylene diphenyl diisocyanate technical MDI pure MDI diisocyanatodiphenylmethane crude MDI monomeric MDI methylenediphenylene diisocyanate polymethylene polyphenyl … It is possible that a harmonisation is introduced through an amendment to the CLP Regulation. Guidance To help minimize the formation of a dimer, an insoluble white solid that may impact the quality of the product, 4,4’-methylene diphenyl diisocyanate (MDI) is usually stored and transported in drums at temperatures below 41°F (5°C). Non-Exhaustive List of Banned Substances, Directive 94/33/EC on Young People at Work, 20 August 1994, as amended by Dir 2014/27/EU, March 5, 2014 (Based on Table 3 of Annex VI to CLP, inter alia), EU. To confirm if a substance is covered by a specific regulatory action the official publication, e.g. Methylenediphenyl 4,4'-Diisocyanate . For a detailed overview on identified uses and environmental releases, please consult the registered substance factsheet. If the substance was not covered by the EC Inventory, ECHA attributes a list number in the same format, starting with the numbers 6, 7, 8 or 9. This section is based on three sources for information (harmonised classification and labelling (CLH), REACH registrations and CLP notifications). Reuzel PGJ, Arts JHE, Kuypers MHM, Kuper CF (1990) Chronic toxicity/carcinogenicity inhalation study of polymeric methylene diphenyl diisocyanate aerosol in rats. Release to the environment of this substance can occur from industrial use: for thermoplastic manufacture, in the production of articles, in processing aids at industrial sites, formulation of mixtures, formulation in materials and as an intermediate step in further manufacturing of another substance (use of intermediates). The EC Inventory is a combination of three independent European lists of substances from the previous EU chemicals regulatory frameworks (EINECS, ELINCS and the NLP-list). These notifications can be provided by manufacturers, importers and downstream users. 66/2010/EC, L 27/1, 30 Jan 2010 (T. 3 of Anx VI to CLP; Candidate List of SVHCs), EU. While the harmonized list covers many hazardous substances, other ones not listed may also meet the classification criteria in accordance with the CLP. InfoCards are generated automatically based on the data available at the time of generation. This website uses cookies to ensure you get the best experience on our websites. Methylene diphenyl diisocyanate (MDI) in commercial form typically exists as a mixture of 4,4'-MDI (monomer) and certain oligomers of MDI (Encyclopedia of Chemical Technology, 1983). REACH Annex XVII. To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email [email protected] or fax 484.881.5997 referencing your VWR account number . Details of substance evaluation by member state competent authorities. Impurities or additives: When a specific critical property is calculated from industry data and where the majority of data submitters have indicated that the property relates to cases containing impurities and/or additives, then the respective critical property icon is modified with an asterisk (*). Polymeric Diphenylmethane Diisocyanate (pMDI) 9016-87-9 50 – 60 4, 4’ Diphenylmethane Diisocyanate (MDI) 101-68-8 35 – 45 2, 4’ Diphenylmethane Diisocyanate (MDI) 5873-54-1 1 – 5 SECTION 4: FIRST AID MEASURES Eye Contact Immediately flush eyes with running water for a minimum of 15 minutes. A substance identified primarily by an EC or list number may be linked with more than one CAS number, or with CAS numbers that have been deleted. The described Product category (i.e. Diagnosis of diisocyanate asthma 203 Appendices (David I. Bernstein) 203 Reading217 4 The environment 229 R E Bailey, A Gard, K H den Haan, F Heimbach, D Pemberton, H Tadokoro, M Takatsuki and Y Yakabe A general approach to environmental risk assessment 229 Exposure 233 Sources of exposure 233 … This database contains substances that have been assigned hazard property (HP) waste codes 1-15, as defined in terms of the hazard class & category, hazard (H) statement, and/or concentration limits provided in Annex III of the Waste Framework Directive (2008/98/EC). What is the Classification and Labelling Inventory? Prohibited Substances: Annex II, Regulation 1223/2009/EC on Cosmetic Products, as amended by Regulation 2019/1966/EU, 28 November 2019, EU. 10. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. While the harmonized list covers many hazardous substances, other ones not listed may also meet the classification criteria in accordance with the CLP. The EU Ecolabel may not be awarded to substances or mixtures classified as such. The ‘Hazard classification’ and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information. Use descriptors are adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes described in Chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment. Examples include recommended measures on fire-fighting, transport and recycling and disposal. More information about Classification and Labelling is available in the Regulations section of ECHA website. A flammable liquid.Isocyanates and thioisocyanates, such as DIPHENYLMETHANE-4,4'-DIISOCYANATE, are incompatible with many classes … Such notifications are required for hazardous substances, mixtures, or articles, manufactured or imported at over 1 kg per annum. in case of consumer and professional uses). This list contains substances to which pregnant workers and workers who have recently given birth or are breastfeeding may not be exposed. Substances for which an agreed set of classification and labelling data has been agreed at EU level by Member States. the electronic edition of the Official Journal of the European Union should be consulted. A substance may have its use restricted to certain articles or products and therefore not all the examples may apply to the specific substance. A prioritisation hierarchy means that data is taken from harmonised C&L data and regulatory lists first, then REACH registrations and finally from CLP notifications. Containers above RQ ship as: Agency Proper Shipping Name UN Number Packing Group Hazard Class . Substances for which certain uses are Restricted under REACH at EU level. %PDF-1.5 %���� The examples provided are generic examples and may not apply to the specific substance you are viewing. Action Plan [RIN 2070-ZA15] I. Overview . Some substance identifiers may have been claimed confidential, or may not have been provided, and therefore not be displayed. DOT Environmentally Hazardous Substance, N.O.S. The 2016 Emergency Response Guidebook, developed jointly by Transport Canada (TC), the U.S. Department of Transportation (DOT), the Secretariat of Communications and Transport of Mexico (SCT) and with the collaboration of CIQUIME (Centro de Información Química para Emergencias) … This substance is used in the following products: adhesives and sealants and coating products. no data available. Methylenediphenyl 4,4 -Diisocyanate 97.0 %, TCI America 25G Chemicals:Organic Compounds:Benzenoids:Benzene and substituted derivatives:Diphenylmethanes 2(b)(i) - Hazardous Agents, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, FCM and Articles Regulation, Annex I - Authorised Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Physical, Biological and Chemical Agents & Processes and Work, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties. 7 and points 2 and 3 of the Annex to Directive 94/33/EC, to which young persons (under 18 years of age) may not be exposed at the workplace. inside a watch) or with very low concentrations considered not to pose risks to human health or the environment. Table 3 of Annex VI to CLP Regulation); and (2) the Candidate List of substances of very high concern (SVHC). machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use. The ‘Hazard classification and labelling’ section shows the hazards of a substance based on the standardised system of statements and pictograms established under the CLP (Classification Labelling and Packaging) Regulation. Please upgrade your Internet Explorer to a newer version. Other release to the environment of this substance is likely to occur from: indoor use (e.g. General Description Diphenylmethane-4,4-diisocyanate is a light yellow colored solid. If generated, an InChI string will also be generated and made available for searching. Gas concentrations are in percent by volume. Furthermore, some substances can be found in an article, but with unlikely exposure (e.g. Methylenediphenyl diisocyanate (MDI) including the following specific isomers (See group members): Previous consultations on ECHA’s Executive Director Requests to the Committees, Applications for authorisation consultations, Harmonised classification and labelling consultations, ECHA Executive Director’s requests related to the CLH process, Consultation on potential candidates for substitution, Consultation on derogation to the exclusion criteria, ECHA's Executive Director Requests to the Committees, Consultation on a draft recommendation for amendment of Authorisation List entries, Consultations in the authorisation process, Occupational exposure limits - Call for comments and evidence, Occupational exposure limits - Previous calls for comments and evidence, Occupational exposure limits – Consultations on OEL recommendation, Derogations for the protection of cultural heritage, ECHA's current activities on restrictions, ECHA's completed activities on restriction, Information on Candidate List substances in articles table, Information from the Existing Substances Regulation (ESR), PBT/vPvB assessments under the previous EU chemicals legislation, Adopted opinions and previous consultations on applications for authorisation, Adopted opinions on restriction proposals, Mapping exercise – Plastic additives initiative, Occupational exposure limits substance evaluations, List of substances subject to POPs Regulation, Small and Medium-sized Enterprises (SMEs), Practical examples of chemical safety reports. This substance is used in the following products: adhesives and sealants and coating products. According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance causes serious eye irritation, is harmful if inhaled, is suspected of causing cancer, may cause damage to organs through prolonged or repeated exposure, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory irritation. 10.2 Chemical stability. MDI, MMDI, Pure >MDI, rein MDI, 4,4'-MDI, Benzene, 1,1'-methylenebis(4-isocyanato-(9CI)), Benzene, 1,1`-methylenebis(4-isocyanato-(9CI), isocyanaic acid, methylene di-p-phenyleneester(6CI,8CI), Isocyanic acid, methylenedi-p-phenylene ester (6CI, 8CI), Isocyanic acid, methylenedi-p-phenylene ester (6CI,8CI), EC Inventory, C&L Inventory, Restriction list, Substance Evaluation - CoRAP, Registration dossier, Pre-Registration process, Other, CAD - Chemical Agents Directive, Art. 92/85/EEC on Pregnant Workers, 28 November 1992 (updated by table 3 of Annex VI to CLP, 5 Oct 2018), EU. Substances listed in the EINECS, ELINCS, or NLP inventories. CHEMTREC operators are available 24 hours a day, seven days a week. The CLP Regulation uses the UN Global Harmonised System (GHS) and European Union Specific Hazard Statements (EUH). MDA is treated with phosgene to give MDI. This is only a partial list; employers are obliged to prevent the exposure of these workers to any agents that may cause adverse health effect for either mother or child. Note that for readability purposes, only the pictograms, signal words and hazard statements referred in more than 5% of the notifications under CLP are displayed. Substances potentially subject to further regulatory management. Note that this list is not exhaustive. The date of the last update corresponds to the publication date of the InfoCard and not necessarily to the date in which the update occurred in the source data. If the substance is covered by more than one CLH entry (e.g. This substance is used in the following products: adhesives and sealants and coating products. Substances Rendering Goods Ineligible for EU Ecolabel, Art. This is unique source of information on the chemicals manufactured and imported in Europe. 117 0 obj <>stream Substances undergoing a PBT/vPvB assessment. 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