Localized aneurysms of the ascending aorta were removed on cardiopulmonary bypass and moderate hypothermia (26–28°C). The present study demonstrates that reoperation and recidives were considerably more frequent in MfS compared to patients with non-fibrillinopathic etiologies of aortic disease. Operative therapy of thoracic aortic aneurysms and dissections are still representing a major surgical challenge associated with a high perioperative mortality. Results: We observed 7 (25.0%, A) versus 35 (14.2%, B) late deaths among the 28 (A) versus 247 (B) early survivors. Five MfS patients (15.2%) and 50 patients (16.8%) of group B presented with aortic arch involvement. An endovascular repair of an abdominal aortic aneurysm isn’t as troubling to consider when compared to the more invasive, … 2018 Jan. 67 (1):2-77.e2. However, complex aortic surgery in the elderly and specifically whether there should be a cut-off age for aortic surgery remains debatable. Journal of Vascular Surgery. In patients who had the sets of preoperative factors that were associated with a 100% mortality rate, there were intraoprative factors that influenced their death. Pneumomediastinum in COVID-19 patients: a case series of a rare complication, 2019 EACTS/EACTA/EBCP guidelines on cardiopulmonary bypass in adult cardiac surgery, Current options and recommendations for the use of thoracic endovascular aortic repair in acute and chronic thoracic aortic disease: an expert consensus document of the European Society for Cardiology (ESC) Working Group of Cardiovascular Surgery, the ESC Working Group on Aorta and Peripheral Vascular Diseases, the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC and the European Association for Cardio-Thoracic Surgery (EACTS), 2020 EACTS/ELSO/STS/AATS expert consensus on post-cardiotomy extracorporeal life support in adult patients, 2019 EACTS Expert Consensus on long-term mechanical circulatory support, About European Journal of Cardio-Thoracic Surgery, About the European Association for Cardio-Thoracic Surgery, About the European Society of Thoracic Surgeons, https://doi.org/10.1016/S1010-7940(98)00043-8, Receive exclusive offers and updates from Oxford Academic, Secondary surgical interventions after endovascular stent-grafting of the thoracic aorta, Clinical outcomes of combined aortic root reimplantation technique and total arch replacement, Inherited diseases and syndromes leading to aortic aneurysms and dissections, Contemporary results of hemiarch replacement, Copyright © 2021 European Association for Cardio-Thoracic Surgery. Aortic aneurysms were present in 11 MfS patients (33.3%). If the diameter has reached or exceeded 4 cm, we perform follow-up examination every 3 months. Hollier LH, Plate G, O'Brien PC, Kazmier FJ, Gloviczki P, Pairolero PC, Cherry KJ. Search for other works by this author on: The Marfan syndrome: diagnosis and management, Fibrillin: a new 350-kD glycoprotein, is a component of extracellular microfibrils, Location on chromosome 15 of the gene defect causing Marfan Syndrome, Genetic linkage of Marfan syndrome, ectopia lentis, and congenital contractural arachnodactyly to the fibrillin genes on chromosomes 15 and 5, Defects in the fibrillin gene cause the Marfan syndrome: linkage evidence and identification of a missense mutation, Linkage of Marfan Syndrome and a phenotypically related disorder to two different fibrillin genes, Localization of the fibrillin (FBN) gene to chromosome 15, band q21.1, The Marfan syndrome locus: confirmation of assignment to chromosome 15 and identification of tightly linked markers at 15q15-q21.3, Cardiovascular manifestations of Marfan’s syndrome in the young, A prospectus on the prevention of aortic rupture in the Marfan Syndrome with data on survivorship without treatment, Life expectancy and causes of death in the Marfan Syndrome, Dissection and dissecting aneurysms of the aorta: twenty-years follow-up of five hundred twenty-seven patients treated surgically, International nosology of heritable disorders of connective tissue, Berlin, 1986, Progression of aortic dilatation and the benefit of long-term ß-adrenergic blockage in Marfan’s syndrome, A technique for complete replacement of the ascending aorta, Successful replacement of the entire ascending aorta and aortic valve, Non parametric estimation from incomplete observations, Surgical management of aortic dissection in patients with the Marfan Syndrome, Surgical treatment of aneurysms of the ascending aorta in the Marfan Syndrome, Composite graft repair of Marfan aneurysm of the ascending aorta: results in 100 patients, Marfan’s syndrome: broad spectral surgical treatment cardiovascular manifestations, Diffuse aneurysmal disease (chronic aortic dissection, Marfan, and mega aorta syndromes) and multiple aneurysm, Surgical treatment of cardiovascular complications in Marfan syndrome: a 27-year experience, Impact of cardiovascular operation on survival in the Marfan patient, Marfan Syndrome: current and future clinical and genetic management of cardiovascular manifestations, Acute and chronic aortic dissections: determinants of long-term outcome for operative survivors. 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